A recent study indicates that individuals who stop using popular slimming jabs like semaglutide or tirzepatide can put back on reduced body mass far faster than those who stop traditional diet and exercise regimens.
Findings released in a leading health publication points out that while obese people often shed about a fifth of their body weight while undergoing treatment, the mass is regained at an estimated rate of 0.8 kg per month once they quit.
"Users using such treatments must be cognizant of the risk of rapid weight regain when the treatment is stopped," warns expert Dr. Susan Jebb.
This pace of regain implies a return to original mass within about one and a half years.
Analyzing Approaches
The research, which examined 37 of trials involving thousands of patients, contrasted the outcomes of the injectable medications with older methods.
Scientists note that individuals who lose weight through dieting usually experience a more gradual weight regain—around 100 grams monthly—after stopping.
The Reason for the Rapid Rebound
Doctors suggest the mode of action of the jabs accounts for the amplified weight return.
These medications imitate a natural hormone called glucagon-like peptide-1, which controls feelings of fullness.
"Long-term administration of the hormone levels far above than the body's typical production may cause the system to generate a reduced amount of its endogenous GLP-1, and may also reduce sensitivity to its effects," explained Dr. Adam Collins, a nutrition specialist.
"Stopping of this hormone supplement results in hunger is no longer kept in check, making overeating a significant risk."
An Ongoing Condition?
The NHS recommend the jabs for people with weight-linked health risks, accompanied by prescribed diet and exercise modifications.
A number of clinicians argue that, due to the likelihood of weight regain, the treatment should be considered life-long.
This view is reinforced by drug manufacturers, who state that the findings "emphasize the long-term character of excess weight," comparing it to managing conditions like hypertension.
Patient Experiences
Users who have discontinued the medication explain a powerful resurgence of cravings.
"I experienced a switch that goes on and you're instantly extremely hungry," described one woman.
This challenge is worsened if users have not developed permanent dietary or behavioural changes during therapy.
Growing Adoption
Figures indicate that millions of people in the UK have tried weight-loss jabs in the last 12 months, with demand continuing to grow.
- Use is greater among women compared to males.
- The 40s and 50s demographic shows the greatest level of interest.
- A large proportion access the medications through private healthcare rather than the NHS.
Finally, clinicians caution that while these medications are effective tools for weight loss, they are not a magic solution and maintained weight loss hinges on ongoing lifestyle changes.
